Embryology in the Quran: Difference between revisions

Meanwhile, the process of limb muscle formation begins as soon as the limb buds appear. Myoblast cells migrate from somites to populate the limb buds. They aggregate into distinct masses, differentiating and fusing into muscle fibres, as the condensing mesenchyme starts to chondrify, and before the resulting cartilage models begin to ossify.

A very detailed account of musculo-skeletal development in the human limb by clinical-geneticist Robert Jan Galjaard covers this subject.<ref>Galjaard, R.J.H. [http://repub.eur.nl/res/pub/10474/030924_Galjaard,%20Robert-Jan%20Harmen.pdf Mapping Studies of Congenital Limb Anomalies]. Ablasserdam: Haveka, B.V., 2003, page 16 [http://www.webcitation.org/6lFwBQq9z webcitation archive link]</ref> It details that muscle precursor cells migrate from the somites into the limb buds (ca. day 26), well before the condensing core of mesenchyme has started to chondrify into cartilage bone models in the upper part of the upper limb (ca. day 37), followed by the lower part (ca. day 41). The myoblasts have grouped into distinct masses by this stage and are differentiating into muscle fibres. The upper limbs later start to ossify (ca. day 54). Chondrification of mesenchyme, the grouping of myogenic masses, and ossification all occur in a proximal-distal order (upper to lower part of each limb). The digits of the hands only start to chondrify ca. day 51.

Professor Peter Law confirms that myoblasts are found in the limb buds day 26.<ref>Law, Peter et al., ''Pioneering Human Myoblast Genome Therapy as a Platform Technology of Regenerative Medicine.'' In: Stem Cell Therapy. Erik Greer (Editor). Nova Science Publishers, Inc. 2006. Page 3.</ref>

Myoblasts have aggregated into ventral and dorsal masses in the upper limb by day 36 and the start of chondrification.<ref>Sivakumar, B. et. al. ''Congenital Hand Differences'' in Farhadieh, R. et. al. (ed.) Plastic and Reconstructive Surgery: Approaches and Techniques, Chichester: Wiley, 2015, p.660 [https://books.google.co.uk/books?id=tCq9BgAAQBAJ&pg=PA660#v=onepage&q&f=false Google books preview]</ref>

A detailed account by Walker and Miranda, including useful diagrams, explains that after day 35, the premuscle regions of the limb containing myoblasts and fibroblasts become distinct, and by day 45 have started to fuse together to become myotubes (which form muscle fibres). With axial musculo-skeletal development, myotomes have migrated (these form axial muscle) and sclerotomes have started to condense into mesenchyme (which will form cartilage) in the 5th week.<ref>Walker, U. A., and Miranda, A. F. ''Muscle Metabolism in the Fetus and Neonate'' in Cowett, R. M. (ed.) Principles of Perinatal-Neonatal Metabolism, 2nd Edition, Volume 1, New York: Springer, 1998, pp.642-643 [https://books.google.co.uk/books?id=eoy-BwAAQBAJ&pg=PA642#v=onepage&q&f=false Google Books preview]</ref>

According to Rugh, Building blocks are present for 40 pairs of muscles, which are located from the base of the skull to the bottom of the spinal column by day 28<ref>Conception to Birth Roberts Rugh, Ph.D., Landrum B. Shettles, Ph.D., M.D. Harper & Row, (New York), 1971, p.35</ref> (these are the myotomes of the somites). Muscles appear in the pelvis day 31<ref>ibid. p.43</ref>. Movement of the muscles is being controlled by the nervous system by the 6th week <ref>ibid. p.34</ref>. All of the muscle blocks have appeared by day 36 after conception<ref>ibid. p.46</ref>.   

 

Firstly, it is clear that bone formation (ossification) begins long after muscle has begun to develop around its precursors. Therefore, there is no scientific basis for the Quranic claim of a stage in which bone is later covered with flesh after its own formation. The prefix fa before kasawna means "and then", indicating an uninterrupted sequence.<ref>فَ fa - [http://www.studyquran.org/LaneLexicon/Volume6/00000105.pdf Lane's Lexicon] Volume 6, page 2322</ref>

Next, if proponents of unerring Quranic embryology suppose that the Quran was only referring to precursor cartilage models of the bones and not bone itself, they have to explain why the author of the Quran mentioned not cartilage (ghudhroof)<ref name="LLghudtroof">غضروف ghudhroof, alternatively spelt غرضوف ghurdoof - [http://www.studyquran.org/LaneLexicon/Volume6/00000032.pdf Lane's Lexicon] Volume 6, page 2248</ref>) but only bone ('itham)<ref name="LLitham"></ref>, which starts to form well after muscles.

In any case its embryology would still be wrong. We have seen that muscle and bone (or their precursors) develop contemporaneously, although the parallel processes start when muscle begins developing around condensations of mesenchyme that have only just begun to differentiate into cartilage, as detailed above.  

For the same reason the Quran would still be wrong even if, with further and unjustifiable generosity, we suppose that it means only the very beginning of the formation of the cartilage (chondrification) before they are in any sense complete shapes. Going back earlier still, it can even be pointed out that the precursors of muscles (myoblasts) and precursors to the cartilage (mesenchyme) are present in the limb bud as soon as it arises.  

Of course, the natural reading of verse 23:14 is that the bones have some sort of meaningful shape, and can meaningfully be called bones. This is certainly not the case when the condensed mesenchyme has merely started to produce cartilage. Furthermore, the natural reading of verse 23:14 is that all the bones have some meaningful presence worthy of the label 'bones' before Allah clothes them with flesh. As noted in the evidence above, fingers only start to even chondrify after muscle formation is already well underway in the upper part of the limbs.